NFL Week 12 Betting Picks, Upset Picks & Analysis (2025)

We run through our top NFL Picks for Week 12, covering our favorite underdogs, spread, and total predictions for the slate.

by Spencer Limbach - Nov 20, 2025

Welcome to our NFL Picks Hub for Week 12. Below, we break down our three favorite moneyline underdogs along with our top against-the-spread and total bets.

Our complete Week 12 player props card (yardage and touchdown props) will be posted in a separate article on Saturday.

Note: This article is available to premium members and users on a free trial. If you’re not currently subscribed, you’ll find a paywall banner below with the option to start a free three-day trial.

NFL Picks Week 12: Published Content

When we publish or update a section, we will list it below with the corresponding date it was posted.

Here’s our NFL Picks Week 12 content so far:

• 11/20: NFL Week 12 Upset Picks
• 11/20: NFL Week 12 Game Picks
• 11/20: Thursday Night Football Breakdown

---

Thursday, Nov. 20

NFL Week 12 Upset Picks

Each week, we spotlight three moneyline underdogs with a realistic shot to win and odds that justify the risk. These bets are more volatile than spreads, but with payouts often 2-3x your stake, you don’t need a high win rate to profit.

Hit just one of three at odds better than +200 and you’re still ahead.

• The tradeoff is variance: we’ve already had a five-game losing streak followed by a 5–1 run this season.

That’s normal for underdogs, which is why disciplined bankroll management is essential.

Odds listed are the market consensus at the time of publication. Always shop around for the best number before you bet.

Three Upset NFL Picks for Week 12