NFL Week 13 Betting Picks, Upset Picks & Analysis (2025)

We break down our top NFL picks for Week 13, including our favorite underdogs, spreads, and totals for the week.

by Spencer Limbach - Nov 26, 2025

Welcome to our NFL Picks Hub for Week 13. Below, we break down our three favorite moneyline underdogs, along with our top against-the-spread and total bets for this week’s slate.

Our full Week 13 player props article (yardage and touchdown props) will be posted separately on Saturday.

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NFL Picks Week 13: Published Content

When we publish or update a section, we will list it below with the corresponding date it was posted.

Here’s our NFL Picks Week 13 content so far:

• 11/26: NFL Week 13 Upset Picks
• 11/26: NFL Week 13 Game Picks
• 11/26: Thursday-Friday Slate Breakdown

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Wednesday, Nov. 26

NFL Week 13 Upset Picks

Each week, we spotlight three moneyline underdogs with a realistic shot to win and odds that justify the risk. These bets are more volatile than spreads, but with payouts often 2-3x your stake, you don’t need a high win rate to profit.

Hit just one of three at odds better than +200 and you’re still ahead.

• The tradeoff is variance: we’ve already had a five-game losing streak followed by a 5–1 run this season.

That’s normal for underdogs, which is why disciplined bankroll management is essential.

Odds listed are the market consensus at the time of publication. Always shop around for the best number before you bet.

Three Upset NFL Picks for Week 13